We are currently seeking a highly motivated and talented cell/molecular biologist within Center for the Development of Therapeutics (CDoT), Translational Sciences team to support Oncology target discovery through the advancement of compounds from PRISM screening platform. The PRISM multiplex screening platform efforts are yielding many hits with provocative predictive biomarkers and patterns of sensitivity. This position will be part of a multidisciplinary team challenged with finding the mechanism of action and/or identifying the target of these hit compounds post screening. Ideally you will have experience in cancer research, and/or signal transduction pathway biology, with expertise in assay development to probe pathway perturbation using genetic and small molecule approaches. You will have a successful track record in working within multidisciplinary teams to advance challenging projects, and will have deep expertise in cellular pharmacology and molecular biology approaches, assays, and technologies. You will function as a bench scientist, and execute assays and activities to advance target discovery and therapeutic programs. Reporting to a Group Leader within Translational Sciences, you will play a key role in driving projects forward within CDoT at the Broad Institute.
The Broad Institute is an amazing place – we exist to apply our deep knowledge of human genetics to empower a revolution in biomedicine and accelerate the pace at which the world conquers disease. The Broad Institute’s CDoT and its team of professional “drug hunters” partner with faculty at MIT, Harvard and the Harvard teaching hospitals to translate emerging biological insights into novel therapeutic strategies. We couple novel technologies and approaches to industry-standard drug discovery rigor to tackle some of the most challenging targets across a wide range of disease areas (including oncology, cardiovascular disease and diabetes, psychiatric disease, infectious disease).
The qualified candidate will have a demonstrated record of cell/molecular biology contributions to target discovery teams to advance screening hits towards leads and candidate drugs, including:
Ph.D. in Cell Biology, Molecular Biology, or Biochemistry, or related life sciences with 0-3 years of research experience beyond post-doctoral training
Oncology research background is required
Working independently to design and execute research plans to ensure that critical project requirements, timelines and deliverables are met
Tracking record with developing hypotheses from omics datasets and evaluating the hypotheses via biological experiments
Hands-on experience with generating gene overexpression/knockout cell lines, maintaining cell lines, and organizing cell banks
Experienced with setting up cell-based experiments to dissect pathways using molecular biology and pharmacological approaches, as well as standard assays (e.g. luminescence-/fluorescence-based cellular readouts, flow cytometry, imaging, etc).
Outstanding verbal and written communication abilities, with experience presenting research plans and results to internal groups as well as external collaborators
Ability to adapt to and effectively manage changes in a fast paced and dynamic environment; ability to act and perform with key information
Strong interpersonal, influencing and collaboration skills to work in a team-oriented, matrixed environment, and the ability to work through conflicts
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